De-orphanization of Cytochrome P450 2r1: a Microsomal Vitamin D 25-hydroxylase
نویسندگان
چکیده
David W. Russell or David J. Mangelsdorf Department of Molecular Genetics Department of Pharmacology UT Southwestern Medical Center UT Southwestern Medical Center 5323 Harry Hines Blvd. 5323 Harry Hines Blvd. Dallas, Texas 75390-9046 Dallas, Texas 75390-9046 Tel. 214 648-2007 Tel. 214 648-6394 Fax. 214 648-6899 E-Mail: Fax 214 648-5419 E-Mail: [email protected] [email protected]
منابع مشابه
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.
The conversion of vitamin D into an active ligand for the vitamin D receptor requires 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney. Mitochondrial and microsomal vitamin D 25-hydroxylase enzymes catalyze the first reaction. The mitochondrial activity is associated with sterol 27-hydroxylase, a cytochrome P450 (CYP27A1); however, the identity of the microsomal enzyme has r...
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